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Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case-Control Consortium (PanC4).


ABSTRACT:

Background

Occupational exposure to acrylamide was associated with excess mortality from pancreatic cancer, though in the absence of dose-risk relationship. Few epidemiological studies have examined the association between acrylamide from diet and pancreatic cancer risk.

Patients and methods

We considered this issue in a combined set of 1975 cases of pancreatic cancer and 4239 controls enrolled in six studies of the Pancreatic Cancer Case-Control Consortium (PanC4). We calculated pooled odds ratios (ORs) and their 95% confidence intervals (CI) by estimating study-specific ORs through multivariate unconditional logistic regression models and pooling the obtained estimates using random-effects models.

Results

Compared with the lowest level of estimated dietary acrylamide intake, the pooled ORs were 0.97 (95% CI, 0.79-1.19) for the second, 0.91 (95% CI, 0.71-1.16) for the third, and 0.92 (95% CI, 0.66-1.28) for the fourth (highest) quartile of intake. For an increase of 10 µg/day of acrylamide intake, the pooled OR was 0.96 (95% CI, 0.87-1.06), with heterogeneity between estimates (I2?=?67%). Results were similar across various subgroups, and were confirmed when using a one-stage modelling approach.

Conclusions

This PanC4 pooled-analysis found no association between dietary acrylamide and pancreatic cancer.

SUBMITTER: Pelucchi C 

PROVIDER: S-EPMC6246541 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case-Control Consortium (PanC4).

Pelucchi C C   Rosato V V   Bracci P M PM   Li D D   Neale R E RE   Lucenteforte E E   Serraino D D   Anderson K E KE   Fontham E E   Holly E A EA   Hassan M M MM   Polesel J J   Bosetti C C   Strayer L L   Su J J   Boffetta P P   Duell E J EJ   La Vecchia C C  

Annals of oncology : official journal of the European Society for Medical Oncology 20170201 2


<h4>Background</h4>Occupational exposure to acrylamide was associated with excess mortality from pancreatic cancer, though in the absence of dose-risk relationship. Few epidemiological studies have examined the association between acrylamide from diet and pancreatic cancer risk.<h4>Patients and methods</h4>We considered this issue in a combined set of 1975 cases of pancreatic cancer and 4239 controls enrolled in six studies of the Pancreatic Cancer Case-Control Consortium (PanC4). We calculated  ...[more]

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