Ontology highlight
ABSTRACT:
SUBMITTER: Serhan CN
PROVIDER: S-EPMC6246799 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Serhan Charles N CN de la Rosa Xavier X Jouvene Charlotte C CC
Journal of immunology (Baltimore, Md. : 1950) 20181024 11
Inflammatory resolution is a process that, when uncontrolled, impacts many organs and diseases. As an active, self-limited inflammatory process, resolution involves biosynthesis of specialized proresolving mediators (SPM) (e.g., lipoxins, resolvins [Rv], protectins, and maresins). Because vagal stimulation impacts inflammation, we examined human and mouse vagus ex vivo to determine if they produce lipid mediators. Using targeted lipid mediator metabololipidomics, we identified lipoxins, Rv, and ...[more]