Ontology highlight
ABSTRACT:
SUBMITTER: Norling LV
PROVIDER: S-EPMC3145138 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Norling Lucy V LV Spite Matthew M Yang Rong R Flower Roderick J RJ Perretti Mauro M Serhan Charles N CN
Journal of immunology (Baltimore, Md. : 1950) 20110401 10
Endogenous microparticles (MPs) were systematically profiled during the time course of self-limited inflammation. Precursors for specialized proresolving lipid mediators were identified in MPs from inflammatory exudates using liquid chromatography tandem mass spectrometry-based metabolomics. Hence, we postulated that formation of anti-inflammatory and proresolving lipid mediators could underlie beneficial effects attributed to MPs and that this process could serve as a basis for biomimicry. Usin ...[more]