Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.
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ABSTRACT:
SUBMITTER: Sahoo BR
PROVIDER: S-EPMC6247814 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.
Sahoo Bikash R BR Genjo Takuya T Bekier Michael M Cox Sarah J SJ Stoddard Andrea K AK Ivanova Magdalena M Yasuhara Kazuma K Fierke Carol A CA Wang Yanzhuang Y Ramamoorthy Ayyalusamy A
Chemical communications (Cambridge, England) 20181101 91
Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the reduced neurotoxicity of nanodisc-bound Aβ oligomers are also reported. ...[more]
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