Ontology highlight
ABSTRACT:
SUBMITTER: Farrell JA
PROVIDER: S-EPMC6247916 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180426 6392
During embryogenesis, cells acquire distinct fates by transitioning through transcriptional states. To uncover these transcriptional trajectories during zebrafish embryogenesis, we sequenced 38,731 cells and developed URD, a simulated diffusion-based computational reconstruction method. URD identified the trajectories of 25 cell types through early somitogenesis, gene expression along them, and their spatial origin in the blastula. Analysis of Nodal signaling mutants revealed that their transcri ...[more]