Ontology highlight
ABSTRACT:
SUBMITTER: Woolsey C
PROVIDER: S-EPMC6249565 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Woolsey Courtney C Geisbert Joan B JB Matassov Demetrius D Agans Krystle N KN Borisevich Viktoriya V Cross Robert W RW Deer Daniel J DJ Fenton Karla A KA Eldridge John H JH Mire Chad E CE Geisbert Thomas W TW
The Journal of infectious diseases 20181101 suppl_5
A recombinant vesicular stomatitis virus (rVSV) expressing the Marburg virus (MARV) Musoke variant glycoprotein fully protects macaques against 2 MARV variants and Ravn virus as a preventive vaccine and MARV variant Musoke as a postexposure treatment. To evaluate postexposure efficacy against the most pathogenic MARV variant, Angola, we engineered rVSVs expressing homologous Angola glycoprotein. Macaques were challenged with high or low doses of variant Angola and treated 20-30 minutes after exp ...[more]