Ontology highlight
ABSTRACT:
SUBMITTER: Wong G
PROVIDER: S-EPMC4564535 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Wong Gary G Richardson Jason S JS Pillet Stéphane S Racine Trina T Patel Ami A Soule Geoff G Ennis Jane J Turner Jeffrey J Qiu Xiangguo X Kobinger Gary P GP
The Journal of infectious diseases 20150509
Ebola virus (EBOV) causes lethal disease in up to 90% of EBOV-infected humans. Among vaccines, only the vesicular stomatitis virus platform has been successful in providing postexposure protection in nonhuman primates. Here, we show that an adjuvanted human adenovirus serotype 5 (Ad5)-vectored vaccine (Ad5-Zaire EBOV glycoprotein) protected 67% (6 of 9) and 25% (1 of 4) of cynomolgus macaques when administered 30 minutes and 24 hours following EBOV challenge, respectively. The treatment also pro ...[more]