In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.
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ABSTRACT:
SUBMITTER: Dyall J
PROVIDER: S-EPMC6249586 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.
Dyall Julie J Johnson Joshua C JC Hart Brit J BJ Postnikova Elena E Cong Yu Y Zhou Huanying H Gerhardt Dawn M DM Michelotti Julia J Honko Anna N AN Kern Steven S DeWald Lisa Evans LE O'Loughlin Kathleen G KG Green Carol E CE Mirsalis Jon C JC Bennett Richard S RS Olinger Gene G GG Jahrling Peter B PB Hensley Lisa E LE
The Journal of infectious diseases 20181101 suppl_5
At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testi ...[more]
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