Ontology highlight
ABSTRACT:
SUBMITTER: Dyall J
PROVIDER: S-EPMC6249586 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20181101 suppl_5
At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testi ...[more]