Ontology highlight
ABSTRACT:
SUBMITTER: Hume A
PROVIDER: S-EPMC6249588 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20181101 suppl_5
Protein kinase R (PKR) is a key antiviral protein involved in sensing and restricting viral infections. Here we analyzed the ability of Marburg virus (MARV) viral protein 35 (VP35) to inhibit PKR activation in human and bat cells. Similar to the related Ebola and Lloviu viruses, MARV VP35 was able to inhibit PKR activation in 293T cells. In contrast, we found that MARV VP35 did not inhibit human or bat PKR activation in human glioblastoma U-251-MG cells or a Rousettus aegyptiacus cell line. Addi ...[more]