Ontology highlight
ABSTRACT:
SUBMITTER: Denton NL
PROVIDER: S-EPMC6249791 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Denton Nicholas L NL Chen Chun-Yu CY Hutzen Brian B Currier Mark A MA Scott Thomas T Nartker Brooke B Leddon Jennifer L JL Wang Pin-Yi PY Srinivas Rachelle R Cassady Kevin A KA Goins William F WF Cripe Timothy P TP
Molecular therapy oncolytics 20181018
Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. We tested the effects of macrophage reduction using liposomal clodronate (Clodrosome) and trabectedin on the antitumor e ...[more]