Ontology highlight
ABSTRACT:
SUBMITTER: Guida MC
PROVIDER: S-EPMC6249795 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Guida Maria Clara MC Hermle Tobias T Graham Laurie A LA Hauser Virginie V Ryan Margret M Stevens Tom H TH Simons Matias M
Molecular biology of the cell 20180711 18
ATP6AP2 (also known as the [pro]renin receptor) is a type I transmembrane protein that can be cleaved into two fragments in the Golgi apparatus. While in Drosophila ATP6AP2 functions in the planar cell polarity (PCP) pathway, recent human genetic studies have suggested that ATP6AP2 could participate in the assembly of the V-ATPase in the endoplasmic reticulum (ER). Using a yeast model, we show here that the V-ATPase assembly factor Voa1 can functionally be replaced by Drosophila ATP6AP2. This re ...[more]