Ontology highlight
ABSTRACT:
SUBMITTER: McKenna MJ
PROVIDER: S-EPMC8053355 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
McKenna Michael J MJ Sim Sue Im SI Ordureau Alban A Wei Lianjie L Harper J Wade JW Shao Sichen S Park Eunyong E
Science (New York, N.Y.) 20200901 6511
Organelle identity depends on protein composition. How mistargeted proteins are selectively recognized and removed from organelles is incompletely understood. Here, we found that the orphan P5A-adenosine triphosphatase (ATPase) transporter ATP13A1 (Spf1 in yeast) directly interacted with the transmembrane segment (TM) of mitochondrial tail-anchored proteins. P5A-ATPase activity mediated the extraction of mistargeted proteins from the endoplasmic reticulum (ER). Cryo-electron microscopy structure ...[more]