Ontology highlight
ABSTRACT:
SUBMITTER: Fowler AM
PROVIDER: S-EPMC6250068 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Fowler Angela M AM Tang William W WW Young Matthew P MP Mamidi Anila A Viramontes Karla M KM McCauley Melanie D MD Carlin Aaron F AF Schooley Robert T RT Swanstrom Jesica J Baric Ralph S RS Govero Jennifer J Diamond Michael S MS Shresta Sujan S
Cell host & microbe 20181101 5
Antibody (Ab)-dependent enhancement can exacerbate dengue virus (DENV) infection due to cross-reactive Abs from an initial DENV infection, facilitating replication of a second DENV. Zika virus (ZIKV) emerged in DENV-endemic areas, raising questions about whether existing immunity could affect these related flaviviruses. We show that mice born with circulating maternal Abs against ZIKV develop severe disease upon DENV infection. Compared with pups of naive mothers, those born to ZIKV-immune mice ...[more]