Dataset Information

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.

ABSTRACT:

Background

The group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality of life (HRQOL) determinants and consequences of HRQOL impairments in long-term CRC survivors may help to individualize survivorship care plans. We aimed to i) examine the HRQOL status of CRC long-term survivors, ii) identify cross-sectional sociodemographic and clinical correlates of HRQOL, and iii) investigate the prospective association of HRQOL after CRC diagnosis with all-cause mortality.

Methods

We assessed HRQOL within a Northern German cohort of 1294 CRC survivors at a median of 6?years after CRC diagnosis using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Cross-sectional correlates of different HRQOL dimensions were analyzed using multivariable-adjusted logistic regression models with HRQOL as a binary variable. With multivariable-adjusted Cox proportional hazards regression models, hazard ratios (HR) of all-cause mortality were estimated per 10-point-increments of an HRQOL summary score, a global quality of life scale, and HRQOL functioning and symptom domains.

Results

The median HRQOL summary score was 87 (interquartile range: 75-94). Sex, age, education, tumor location, metastases, other cancers, type of therapy, and current stoma were identified as correlates of different HRQOL scales. After a median follow-up time of 7?years after HRQOL assessment, 175 participants had died. Nearly all HRQOL domains, except for cognitive functioning and diarrhea, were significantly associated with all-cause mortality. A 10-point-increment in the summary score decreased the risk of death by 24% (HR: 0.76; 95% CI: 0.70-0.82).

Conclusions

HRQOL in CRC survivors appeared to be relatively high in the long term. Various clinical and sociodemographic factors were cross-sectionally associated with HRQOL in long-term CRC survivors. Lower HRQOL was associated with increased all-cause mortality. Individualized healthcare programs for CRC survivors (including psychosocial screening and interventions) are needed to detect decreased HRQOL and to further improve long-term HRQOL and survival.

SUBMITTER: Ratjen I

PROVIDER: S-EPMC6251222 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.

Ratjen Ilka I Schafmayer Clemens C Enderle Janna J di Giuseppe Romina R Waniek Sabina S Koch Manja M Burmeister Greta G Nöthlings Ute U Hampe Jochen J Schlesinger Sabrina S Lieb Wolfgang W

BMC cancer 20181122 1

<h4>Background</h4>The group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality of life (HRQOL) determinants and consequences of HRQOL impairments in long-term CRC survivors may help to individualize survivorship care plans. We aimed to i) examine the HRQOL status of CRC long-term survivors, ii) identify cross-sectional sociodemographic and clinical correlates of HRQOL, and iii) investigate the prospective association of HRQOL after CRC diagnos ...[more]

PMID: 30466408

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Dataset Information

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.

Background

Methods

Results

Conclusions

Publications

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.

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