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Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure.

ABSTRACT: Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on the virus. This result has implications for the induction of ADCC responses by HIV vaccines.

SUBMITTER: Chung AW

PROVIDER: S-EPMC3088575 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure.

Chung Amy W AW Isitman Gamze G Navis Marjon M Kramski Marit M Center Rob J RJ Kent Stephen J SJ Stratov Ivan I

Proceedings of the National Academy of Sciences of the United States of America 20110418 18

Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope d ...[more]

PMID: 21502492

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