Ontology highlight
ABSTRACT:
SUBMITTER: Zeng M
PROVIDER: S-EPMC6251623 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zeng Mei M Kwiatkowski Nicholas P NP Zhang Tinghu T Nabet Behnam B Xu Mousheng M Liang Yanke Y Quan Chunshan C Wang Jinhua J Hao Mingfeng M Palakurthi Sangeetha S Zhou Shan S Zeng Qing Q Kirschmeier Paul T PT Meghani Khyati K Leggett Alan L AL Qi Jun J Shapiro Geoffrey I GI Liu Joyce F JF Matulonis Ursula A UA Lin Charles Y CY Konstantinopoulos Panagiotis A PA Gray Nathanael S NS
eLife 20181113
High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of <i>MYC</i> oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their oncogenic growth, indicating MYC as a therapeutic target for this difficult-to-treat malignancy. However, targeting MYC directly has proven difficult. We screen small molecules targeting transcriptional and epigenetic regulation, and find tha ...[more]