On the use of abiotic sialic acids to attenuate cell inflammation.
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ABSTRACT:
SUBMITTER: Xue Z
PROVIDER: S-EPMC6251910 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
On the use of abiotic sialic acids to attenuate cell inflammation.
Xue Zhongwei Z Zhao Hu H Zhu Rui R Chen Congcong C Cao Hongzhi H Han Jiahuai J Han Shoufa S
Scientific reports 20181123 1
Sialic acid (Sia) residues on cell surface are critical for myriad cellular events such as immunity and inflammation. We herein reported the use of abiotic Sia to raise the thresholds of inflammatory cell responses. Identified from a panel of structurally diversified Sia analogs via a cell inflammation assay, Sia-2, with N-butyryl moiety at C-5, markedly lowered LPS-stimulated NF-κB activity in macrophages. Further analysis shows that Sia-2 attenuates phosphorylation of IκB and Erk1/2/p38/JNK, c ...[more]
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