Dataset Information

Simultaneous T1 and T2 mapping of the carotid plaque (SIMPLE) with T2 and inversion recovery prepared 3D radial imaging.

ABSTRACT: PURPOSE:To propose a technique that can produce different T1 and T2 contrasts in a single scan for simultaneous T1 and T2 mapping of the carotid plaque (SIMPLE). METHODS:An interleaved 3D golden angle radial trajectory was used in conjunction with T2 preparation with variable duration (TEprep ) and inversion recovery pulses. Sliding window reconstruction was adopted to reconstruct images at different inversion delay time and TEprep for joint T1 and T2 fitting. In the fitting procedure, a rapid B1 correction method was presented. The accuracy of SIMPLE was investigated in phantom experiments. In vivo scans were performed on 5 healthy volunteers with 2 scans each, and on 5 patients with carotid atherosclerosis. RESULTS:The phantom T1 and T2 estimations of SIMPLE agreed well with the standard methods with the percentage difference smaller than 7.1%. In vivo T1 and T2 for normal carotid vessel wall were 1213?±?48.3 ms and 51.1?±?1.7 ms, with good interscan repeatability. Alternations of T1 and T2 in plaque regions were in agreement with the conventional multicontrast imaging findings. CONCLUSION:The proposed SIMPLE allows simultaneous T1 and T2 mapping of the carotid artery in less than 10 minutes, serving as a quantitative tool with good accuracy and reproducibility for plaque characterization.

SUBMITTER: Qi H

PROVIDER: S-EPMC6252279 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Simultaneous T<sub>1</sub> and T<sub>2</sub> mapping of the carotid plaque (SIMPLE) with T<sub>2</sub> and inversion recovery prepared 3D radial imaging.

Qi Haikun H Sun Jie J Qiao Huiyu H Zhao Xihai X Guo Rui R Balu Niranjan N Yuan Chun C Chen Huijun H

Magnetic resonance in medicine 20180525 6

<h4>Purpose</h4>To propose a technique that can produce different T<sub>1</sub> and T<sub>2</sub> contrasts in a single scan for simultaneous T<sub>1</sub> and T<sub>2</sub> mapping of the carotid plaque (SIMPLE).<h4>Methods</h4>An interleaved 3D golden angle radial trajectory was used in conjunction with T<sub>2</sub> preparation with variable duration (TE<sub>prep</sub> ) and inversion recovery pulses. Sliding window reconstruction was adopted to reconstruct images at different inversion delay ...[more]

PMID: 29802629

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Project description:BACKGROUND AND PURPOSE:Techniques to stratify subgroups of patients with asymptomatic carotid artery disease are urgently needed to guide decisions on optimal treatment. Reliance on estimates of % luminal stenosis has not been effective, perhaps because that approach entirely disregards potentially important information on the pathological process in the wall of the artery. METHODS:Since plaque lipid is a key determinant of plaque behaviour we used a newly validated, high-sensitivity T2-mapping MR technique for a systematic survey of the quantity and distribution of plaque lipid in patients undergoing endarterectomy. Lipid percentage was quantified in 50 carotid endarterectomy patients. Lipid distribution was tested, using two imaging indices (contribution of the largest lipid deposit towards total lipid (LLD %) and a newly-developed LAI 'lipid aggregation index'). RESULTS:The bifurcation contained maximal lipid volume. Lipid percentage was higher in symptomatic vs. asymptomatic patients with degree of stenosis (DS ? 50%) and in the total cohort (P = 0.013 and P = 0.005, respectively). Both LLD % and LAI was higher in symptomatic patients (P = 0.028 and P = 0.018, respectively), suggesting that for a given plaque lipid volume, coalesced deposits were more likely to be associated with symptomatic events. There was no correlation between plaque volume or lipid content and degree of luminal stenosis measured on ultrasound duplex (r = -0.09, P = 0.53 and r = -0.05, P = 0.75), respectively. However, there was a strong correlation in lipid between left and right carotid arteries (r = 0.5, P <0.0001, respectively). CONCLUSIONS:Plaque lipid content and distribution is associated with symptomatic status of the carotid plaque. Importantly, plaque lipid content was not related to the degree of luminal stenosis assessed by ultrasound. Determination of plaque lipid content may prove useful for stratification of asymptomatic patients, including selection of optimal invasive treatments.

Dataset Information

Simultaneous T1 and T2 mapping of the carotid plaque (SIMPLE) with T2 and inversion recovery prepared 3D radial imaging.

Publications

Simultaneous T<sub>1</sub> and T<sub>2</sub> mapping of the carotid plaque (SIMPLE) with T<sub>2</sub> and inversion recovery prepared 3D radial imaging.

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