Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC6252322 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhou Ying Y Hu Pei P Huang Yuguang Y Nuoer Sang S Song Kaicheng K Wang Hongyun H Wen Jinhua J Jiang Ji J Chen Xia X
Frontiers in pharmacology 20181119
HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives. To avoid inadequate anesthesia and predict return of cognition, allowing for immediate neurological evaluation, HR7056 pharmacokinetics and pharmacodynamics were characterized in Chinese healthy subjects. We report on modeling of the data and simulations of dosage regimens for future study. Up to 63 subjects were evaluated, using Bispectral Index (BIS) and Modified Obser ...[more]