Ontology highlight
ABSTRACT:
SUBMITTER: Moulton JD
PROVIDER: S-EPMC6253989 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20090325 3
Antisense molecules do not readily cross cell membranes. This has limited the use of antisense to systems where techniques have been worked out to introduce the molecules into cells, such as embryos and cell cultures. Uncharged antisense bearing a group of guanidinium moieties on either a linear peptide or dendrimer scaffold can enter cells by endocytosis and subsequently escape from endosomes into the cytosol/nuclear compartment of cells. These technologies allow systemic administration of anti ...[more]