Ontology highlight
ABSTRACT:
SUBMITTER: Kondaparla S
PROVIDER: S-EPMC6256754 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kondaparla Srinivasarao S Debnath Utsab U Soni Awakash A Dola Vasantha Rao VR Sinha Manish M Srivastava Kumkum K Puri Sunil K SK Katti Seturam B SB
Antimicrobial agents and chemotherapy 20181126 12
In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents. <i>In vitro</i> as well as <i>in vivo</i> studies revealed that compound 7c showed potent activity (<i>in vitro</i> 50% inhibitory concentration, 56.98 nM for strain 3D7 and 97.76 nM for strain K1; selectivity index <i>in vivo</i> [up to at a dose of 12.5 mg/kg of body weight], 3,510) as a new lead antimalarial agent. ...[more]