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ABSTRACT:
SUBMITTER: Bekhit AA
PROVIDER: S-EPMC9427035 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Bekhit Adnan A AA Lodebo Eskedar T ET Hymete Ariaya A Ragab Hanan M HM Bekhit Salma A SA Amagase Kikuko K Batubara Afnan A Abourehab Mohammed A S MAS Bekhit Alaa El-Din A AEA Ibrahim Tamer M TM
Journal of enzyme inhibition and medicinal chemistry 20221201 1
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of <i>in vivo</i> antimalarial activities of new pyrazolylpyrazoline derivatives against <i>Plasmodium berghei</i> infected mice. Further evaluation of <b>5b</b> and <b>6a</b> against chloroquine-resistant strain (RKL9) of <i>P. falciparum</i> showed higher potency than chloroquine. <i>In vitro</i> antileishmanial activity testing against <i>Leishmania aethiopica</i> promastigote and amastigote forms ind ...[more]