Ontology highlight
ABSTRACT:
SUBMITTER: Bartelt LA
PROVIDER: S-EPMC6256802 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bartelt Luther A LA Bolick David T DT Kolling Glynis L GL Stebbins Erin E Huston Christopher D CD Guerrant Richard L RL Hoffman Paul S PS
Antimicrobial agents and chemotherapy 20181126 12
<i>Cryptosporidium</i> species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes <i>Cryptosporidium</i> infection severity in a malnourished mouse model despite a lack of direct anticryptosporidial activity. We suggest that amixicile, by tamping down anaerobes associated w ...[more]