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Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium.


ABSTRACT: Cryptosporidium species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes Cryptosporidium infection severity in a malnourished mouse model despite a lack of direct anticryptosporidial activity. We suggest that amixicile, by tamping down anaerobes associated with intestinal inflammation, reverses weight loss and indirectly mitigates infection-associated pathology.

SUBMITTER: Bartelt LA 

PROVIDER: S-EPMC6256802 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have <i>In Vitro</i> Activity against Cryptosporidium.

Bartelt Luther A LA   Bolick David T DT   Kolling Glynis L GL   Stebbins Erin E   Huston Christopher D CD   Guerrant Richard L RL   Hoffman Paul S PS  

Antimicrobial agents and chemotherapy 20181126 12


<i>Cryptosporidium</i> species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes <i>Cryptosporidium</i> infection severity in a malnourished mouse model despite a lack of direct anticryptosporidial activity. We suggest that amixicile, by tamping down anaerobes associated w  ...[more]

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