Ontology highlight
ABSTRACT:
SUBMITTER: Abu Sheikha G
PROVIDER: S-EPMC6257782 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Abu Sheikha Ghassan G Abu Khalaf Reema R Melhem Areej A Albadawi Ghadeer G
Molecules (Basel, Switzerland) 20100819 8
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previously-reported pharmacophore and QSAR models for CETP inhibition, we synthesized and bioassayed a series of benzylamino-methanones. The most potent illustrated 30% CETP inhibition at 10 microM. ...[more]