Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.
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ABSTRACT:
SUBMITTER: Thompson CF
PROVIDER: S-EPMC4018150 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
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Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.
Thompson Christopher F CF Ali Amjad A Quraishi Nazia N Lu Zhijian Z Hammond Milton L ML Sinclair Peter J PJ Anderson Matt S MS Eveland Suzanne S SS Guo Qiu Q Hyland Sheryl A SA Milot Denise P DP Sparrow Carl P CP Wright Samuel D SD
ACS medicinal chemistry letters 20110324 6
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (<100 nM IC50 for the inhibition of CE transfer) CETP inhibitor scaffold c ...[more]
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