Ontology highlight
ABSTRACT:
SUBMITTER: Salinas-Hernandez XI
PROVIDER: S-EPMC6257816 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Salinas-Hernández Ximena I XI Vogel Pascal P Betz Sebastian S Kalisch Raffael R Sigurdsson Torfi T Duvarci Sevil S
eLife 20181113
Extinction of fear responses is critical for adaptive behavior and deficits in this form of safety learning are hallmark of anxiety disorders. However, the neuronal mechanisms that initiate extinction learning are largely unknown. Here we show, using single-unit electrophysiology and cell-type specific fiber photometry, that dopamine neurons in the ventral tegmental area (VTA) are activated by the omission of the aversive unconditioned stimulus (US) during fear extinction. This dopamine signal o ...[more]