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Cerebral A?₄₀ and systemic hypertension.

ABSTRACT: Mid-life hypertension and cerebral hypoperfusion may be preclinical abnormalities in people who later develop Alzheimer's disease. Although accumulation of amyloid-beta (A?) is characteristic of Alzheimer's disease and is associated with upregulation of the vasoconstrictor peptide endothelin-1 within the brain, it is unclear how this affects systemic arterial pressure. We have investigated whether infusion of A?₄₀ into ventricular cerebrospinal fluid modulates blood pressure in the Dahl salt-sensitive rat. The Dahl salt-sensitive rat develops hypertension if given a high-salt diet. Intracerebroventricular infusion of A? induced a progressive rise in blood pressure in rats with pre-existing hypertension produced by a high-salt diet ( p?

SUBMITTER: Tayler HM

PROVIDER: S-EPMC6259324 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Cerebral Aβ40 and systemic hypertension.

Tayler Hannah M HM Palmer Jennifer C JC Thomas Taya L TL Kehoe Patrick G PG Paton Julian Fr JF Love Seth S

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170807 11

Mid-life hypertension and cerebral hypoperfusion may be preclinical abnormalities in people who later develop Alzheimer's disease. Although accumulation of amyloid-beta (Aβ) is characteristic of Alzheimer's disease and is associated with upregulation of the vasoconstrictor peptide endothelin-1 within the brain, it is unclear how this affects systemic arterial pressure. We have investigated whether infusion of Aβ40 into ventricular cerebrospinal fluid modulates blood pressure in the Da ...[more]

PMID: 28782443

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