Unknown

Dataset Information

0

From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction.


ABSTRACT: Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. In the past decade, this hypothesis has been studied using contemporary circulatory support pumps. We will review the most recent series of preclinical studies in the field which led to the recently completed Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) safety and feasibility pilot trial.

SUBMITTER: Kapur NK 

PROVIDER: S-EPMC6259487 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction.

Kapur Navin K NK   Annamalai Shiva S   Reyelt Lara L   Karmiy Samuel J SJ   Razavi Allen A AA   Foroutanjazi Sina S   Chennojwala Aditya A   Ishikawa Kiyotake K  

F1000Research 20181127


Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970's, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. In the past decade, this hypothesis has been studied using contemporary circulatory support pumps. We will revi  ...[more]

Similar Datasets

| S-EPMC7830975 | biostudies-literature
| S-EPMC8421131 | biostudies-literature
| S-EPMC6727167 | biostudies-literature
| S-EPMC5394927 | biostudies-other
| S-EPMC4849631 | biostudies-literature
| S-EPMC5822961 | biostudies-literature
| S-EPMC9844382 | biostudies-literature
| S-EPMC7554763 | biostudies-literature
| S-EPMC8057442 | biostudies-literature
| S-EPMC6275042 | biostudies-literature