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Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila.

ABSTRACT: A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3-4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1-4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.

SUBMITTER: Wang CC

PROVIDER: S-EPMC6260601 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila.

Wang Cui-Cui CC Liu Hai-Zhou HZ Liu Ming M Zhang Yu-Yan YY Li Tian-Tian TT Lin Xiu-Kun XK

Molecules (Basel, Switzerland) 20110330 4

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3-4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1-4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PAN ...[more]

PMID: 21455093

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