Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz R
PROVIDER: S-EPMC6261649 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ruiz Raul R de la Cruz Fernando F Fernandez-Lopez Raul R
Science advances 20181128 11
In the cell, noise constrains information transmission through signaling pathways and regulatory networks. There is growing evidence that the channel capacity of cellular pathways is limited to a few bits, questioning whether cells quantify external stimuli or rely on threshold detection and binary on/off decisions. Here, using fluorescence microscopy and information theory, we analyzed the ability of the transcriptional regulator TetR to sense and quantify the antibiotic tetracycline. The resul ...[more]