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Directed formation of DNA nanoarrays through orthogonal self-assembly.

ABSTRACT: We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

SUBMITTER: Burns JR

PROVIDER: S-EPMC6264196 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Directed formation of DNA nanoarrays through orthogonal self-assembly.

Burns Jonathan R JR Zekonyte Jurgita J Siligardi Giuliano G Hussain Rohanah R Stulz Eugen E

Molecules (Basel, Switzerland) 20110615 6

We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy- ...[more]

PMID: 21677604

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