Ontology highlight
ABSTRACT:
SUBMITTER: Klement JD
PROVIDER: S-EPMC6264631 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Klement John D JD Paschall Amy V AV Redd Priscilla S PS Ibrahim Mohammed L ML Lu Chunwan C Yang Dafeng D Celis Esteban E Abrams Scott I SI Ozato Keiko K Liu Kebin K
The Journal of clinical investigation 20181105 12
Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human cancers respond to ICI immunotherapy and a large fraction of patients with the responsive types of cancers do not respond to current ICI immunotherapy. This clinical conundrum suggests that additional immune checkpoints exist. We report here that interferon regulatory factor 8 (IRF8) deficiency led to impairment of cytotoxic T lymphocyte (CTL) activation and allograft tumor tolerance. However, analysis of chi ...[more]