Ontology highlight
ABSTRACT:
SUBMITTER: Pourchet A
PROVIDER: S-EPMC4816761 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
EBioMedicine 20160119
Although counteracting innate defenses allows oncolytic viruses (OVs) to better replicate and spread within tumors, CD8(+) T-cells restrict their capacity to trigger systemic anti-tumor immune responses. Herpes simplex virus-1 (HSV-1) evades CD8(+) T-cells by producing ICP47, which limits immune recognition of infected cells by inhibiting the transporter associated with antigen processing (TAP). Surprisingly, removing ICP47 was assumed to benefit OV immuno-therapy, but the impact of inhibiting T ...[more]