Heterologous Hsp90 promotes phenotypic diversity through network evolution.
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ABSTRACT:
SUBMITTER: Koubkova-Yu TC
PROVIDER: S-EPMC6264905 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Heterologous Hsp90 promotes phenotypic diversity through network evolution.
Koubkova-Yu Tracy Chih-Ting TC Chao Jung-Chi JC Leu Jun-Yi JY
PLoS biology 20181115 11
Biological processes in living cells are often carried out by gene networks in which signals and reactions are integrated through network hubs. Despite their functional importance, it remains unclear to what extent network hubs are evolvable and how alterations impact long-term evolution. We investigated these issues using heat shock protein 90 (Hsp90), a central hub of proteostasis networks. When native Hsp90 in Saccharomyces cerevisiae cells was replaced by the ortholog from hypersaline-tolera ...[more]
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