Ontology highlight
ABSTRACT:
SUBMITTER: Diaz N
PROVIDER: S-EPMC6265268 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181129 1
Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation. However, our ability to examine its biological function and role in disease is limited by the large amounts of starting material required to perform current experimental approaches. Here, we present Low-C, a Hi-C method for low amounts of input material. By systematically comparing Hi-C libraries made with decreasing amounts of starting material we show that Low-C is highly reproducible and robust to experime ...[more]