Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC6265463 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20181101 21
Although the host restriction factor APOBEC3G (A3G) has broad spectrum antiviral activity, whether A3G inhibits enterovirus 71 (EV71) has been unclear until now. In this study, we demonstrated for the first time that A3G could inhibit EV71 virus replication. Silencing A3G in H9 cells enhanced EV71 replication, and EV71 replication was lower in H9 cells expressing A3G than in Jurkat cells without A3G expression, indicating that the EV71 inhibition was A3G-specific. Further investigation revealed ...[more]