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Carbotoxicity-Noxious Effects of Carbohydrates.


ABSTRACT: Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as "carbotoxicity." Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as well as the beneficial effects of reducing carbs in the diet. We discuss the molecular, cellular, and neuroendocrine mechanisms that link exaggerated carbohydrate intake to disease and accelerated aging as we outline dietary and pharmacologic strategies to combat carbotoxicity.

SUBMITTER: Kroemer G 

PROVIDER: S-EPMC6265656 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Carbotoxicity-Noxious Effects of Carbohydrates.

Kroemer Guido G   López-Otín Carlos C   Madeo Frank F   de Cabo Rafael R  

Cell 20181001 3


Modern nutrition is often characterized by the excessive intake of different types of carbohydrates ranging from digestible polysaccharides to refined sugars that collectively mediate noxious effects on human health, a phenomenon that we refer to as "carbotoxicity." Epidemiological and experimental evidence combined with clinical intervention trials underscore the negative impact of excessive carbohydrate uptake, as well as the beneficial effects of reducing carbs in the diet. We discuss the mol  ...[more]

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