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Immediate effects of noxious and innocuous thermal stimulation on brain activation in patients with stroke.


ABSTRACT: Case-control studies have shown that noxious thermal stimulation (TS) can improve arm function in patients with stroke. However, the neural mechanisms underlying this improvement are largely unknown. We explored functional neural activation due to noxious and innocuous TS intervention applied to the paretic arm of patients with stroke. Sixteen participants with unilateral cortical infarctions were allocated to one of two groups: noxious TS (8 patients; temperature combination: hot pain 46°C to 47°C, cold pain 7°C-8°C) or innocuous TS (n?=?8; temperature combination: hot 40°C-41°C, cold 20°C-21°C). All subjects underwent fMRI scanning before and after 30?min TS intervention and performed a finger tapping task with the affected hand. Immediate brain activation effects were assessed according to thermal type (noxious vs. innocuous TS) and time (pre-TS vs post-TS). Regions activated by noxious TS relative to innocuous TS (P?

SUBMITTER: Chen SC 

PROVIDER: S-EPMC7478460 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Immediate effects of noxious and innocuous thermal stimulation on brain activation in patients with stroke.

Chen Sharon Chia-Ju SC   Hsu Miao-Ju MJ   Kuo Yu-Ting YT   Lin Ruey-Tay RT   Lo Sing-Kai SK   Lin Jau-Hong JH  

Medicine 20200201 9


Case-control studies have shown that noxious thermal stimulation (TS) can improve arm function in patients with stroke. However, the neural mechanisms underlying this improvement are largely unknown. We explored functional neural activation due to noxious and innocuous TS intervention applied to the paretic arm of patients with stroke. Sixteen participants with unilateral cortical infarctions were allocated to one of two groups: noxious TS (8 patients; temperature combination: hot pain 46°C to 4  ...[more]

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