Dataset Information

Occupational class and risk of renal cell cancer.

ABSTRACT:

Objectives

We sought to examine the association between occupational class linked to job stress and the risk of renal cell cancer. To identify potential mediators, we additionally examined whether any observed associations persisted even after controlling for the contribution of stress-related factors (eg, smoking, hypertension, and obesity).

Methods

Using nationwide inpatient records (1984 to 2016) from the Rosai Hospital group in Japan, we identified 3316 cases of renal cell cancer (excluding upper tract urothelial cancer) and 168 418 controls. We classified patients' occupational class (blue-collar workers, service workers, professionals, and managers) and cross-classified it by industry type (blue-collar, service, and white-collar) based on a standardized national classification. Unconditional logistic regression with multiple imputation was used for the analyses.

Results

A significantly elevated risk of renal cell cancer was found among men in higher occupational class (eg, professionals and managers). The elevated odds in male managers across all industries persisted even after controlling for smoking and alcohol consumption, with the association being more pronounced in blue-collar industries (OR, 1.61; 95% CI, 1.34-1.93). The association appeared to be mainly mediated by hypertension.

Conclusion

Occupational class is associated with the risk of renal cell cancer in men, particularly through modifiable risk factors.

SUBMITTER: Zaitsu M

PROVIDER: S-EPMC6266576 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Occupational class and risk of renal cell cancer.

Zaitsu Masayoshi M Cuevas Adolfo G AG Trudel-Fitzgerald Claudia C Takeuchi Takumi T Kobayashi Yasuki Y Kawachi Ichiro I

Health science reports 20180516 6

<h4>Objectives</h4>We sought to examine the association between occupational class linked to job stress and the risk of renal cell cancer. To identify potential mediators, we additionally examined whether any observed associations persisted even after controlling for the contribution of stress-related factors (eg, smoking, hypertension, and obesity).<h4>Methods</h4>Using nationwide inpatient records (1984 to 2016) from the Rosai Hospital group in Japan, we identified 3316 cases of renal cell can ...[more]

PMID: 30623081

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Project description:BackgroundAgricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides.ObjectiveWe evaluated the lifetime use of individual pesticides and the incidence of RCC.MethodsWe evaluated the associations between intensity-weighted lifetime days (IWDs) of 38 pesticides and incident RCC in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina. Among 55,873 applicators, 308 cases were diagnosed between enrollment (1993-1997) and the end of follow-up (2014-2015). We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) using Poisson regression, controlling for potential confounding factors, with lagged and unlagged pesticide exposures.ResultsThere was a statistically significant increased risk of RCC among the highest users of 2,4,5-T compared with never users [unlagged RRIWD Tertile 3=2.92 (95% CI: 1.65, 5.17; ptrend=0.001)], with similar risk estimates for lagged exposure [20-y lag RRIWD Tertile 3=3.37 (95% CI: 1.83, 6.22; ptrend=0.001)]. In 20-y lagged analyses, we also found exposure-response associations with chlorpyrifos [RRIWD Quartile 4=1.68 (95% CI: 1.05, 2.70; ptrend=0.01)], chlordane [RRIWD Tertile 3=2.06 (95% CI: 1.10, 3.87; ptrend=0.02)], atrazine [RRIWD Quartile 4=1.43 (95% CI: 1.00, 2.03; ptrend=0.02)], cyanazine [RRIWD Quartile 4=1.61 (95% CI: 1.03, 2.50; ptrend=0.02)], and paraquat [RRIWD>Median=1.95 (95% CI: 1.03, 3.70; ptrend=0.04)].ConclusionsThis is, to our knowledge, the first prospective study to evaluate RCC risk in relation to various pesticides. We found evidence of associations with RCC for four herbicides (2,4,5-T, atrazine, cyanazine, and paraquat) and two insecticides (chlorpyrifos and chlordane). Our findings provide insights into specific chemicals that may influence RCC risk among pesticide applicators. Confirmation of these findings and investigations of the biologic plausibility and potential mechanisms underlying the observed associations are warranted. https://doi.org/10.1289/EHP6334.

Dataset Information

Occupational class and risk of renal cell cancer.

Objectives

Methods

Results

Conclusion

Publications

Occupational class and risk of renal cell cancer.

Similar Datasets

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