Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation.
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ABSTRACT:
SUBMITTER: Razak AM
PROVIDER: S-EPMC6267085 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Targeting myomiRs by tocotrienol-rich fraction to promote myoblast differentiation.
Razak Azraul Mumtazah AM Khor Shy Cian SC Jaafar Faizul F Karim Norwahidah Abdul NA Makpol Suzana S
Genes & nutrition 20181129
<h4>Background</h4>Several muscle-specific microRNAs (myomiRs) are differentially expressed during cellular senescence. However, the role of dietary compounds on myomiRs remains elusive. This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on myomiRs and myogenic genes during differentiation of human myoblasts. Young and senescent human skeletal muscle myoblasts (HSMM) were treated with 50 μg/mL TRF for 24 h before and after inducing differentiation.<h4>Results</h ...[more]
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