Ontology highlight
ABSTRACT:
SUBMITTER: Zheng DQ
PROVIDER: S-EPMC6267110 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zheng Dao-Qiong DQ Petes Thomas D TD
Genes 20181107 11
Most cells of solid tumors have very high levels of genome instability of several different types, including deletions, duplications, translocations, and aneuploidy. Much of this instability appears induced by DNA replication stress. As a model for understanding this type of instability, we have examined genome instability in yeast strains that have low levels of two of the replicative DNA polymerases: DNA polymerase α and DNA polymerase δ (Polα and Polδ). We show that low levels of either of th ...[more]