Ontology highlight
ABSTRACT:
SUBMITTER: Santos JA
PROVIDER: S-EPMC7694242 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Santos Joana A JA Lamers Meindert H MH
Antibiotics (Basel, Switzerland) 20201104 11
Multidrug resistance is a worldwide problem that is an increasing threat to global health. Therefore, the development of new antibiotics that inhibit novel targets is of great urgency. Some of the most successful antibiotics inhibit RNA transcription, RNA translation, and DNA replication. Transcription and translation are inhibited by directly targeting the RNA polymerase or ribosome, respectively. DNA replication, in contrast, is inhibited indirectly through targeting of DNA gyrases, and there ...[more]