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Diphenyl Ethers from a Marine-Derived Aspergillus sydowii.

ABSTRACT: Six new diphenyl ethers (1?6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1?3 was determined by a LC-MS method. All the compounds were evaluated for their cytotoxicities against eight cancer cell lines, including 4T1, U937, PC3, HL-60, HT-29, A549, NCI-H460, and K562, and compounds 1, 5, 6, and 8?11 were found to exhibit selective cytotoxicity against different cancer cell lines.

SUBMITTER: Wang YN

PROVIDER: S-EPMC6267227 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Diphenyl Ethers from a Marine-Derived Aspergillus sydowii.

Wang Ya-Nan YN Mou Yan-Hua YH Dong Yu Y Wu Yan Y Liu Bing-Yu BY Bai Jian J Yan Dao-Jiang DJ Zhang Le L Feng Dan-Qing DQ Pei Yue-Hu YH Hu You-Cai YC

Marine drugs 20181116 11

Six new diphenyl ethers (1⁻6) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived Aspergillus sydowii guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds 1 and 2 are rare diphenyl ether glycosides containing d-ribose. The absolute configuration of the sugar moieties in compounds 1⁻3 was determined by a LC-MS method. All the ...[more]

PMID: 30453472

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