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Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus Aspergillus tennesseensis.

ABSTRACT: Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure-diorcinol L (1) and (R)-diorcinol B (2)-were isolated from the marine algal-derived endophytic fungus Aspergillus tennesseensis, along with seven known compounds: (S)-diorcinol B (3), 9-acetyldiorcinol B (4), diorcinol C (5), diorcinol D (6), diorcinol E (7), diorcinol J (8), and a dihydrobenzofuran derivative 9. Their structures were elucidated by extensive NMR spectroscopy studies. Compound 2 represents the first example of an R-configuration in the prenylated moiety. All these isolated compounds were examined for antimicrobial and cytotoxic activities. Compounds 1?9 exhibited antimicrobial activities against some human- and plant-pathogenic microbes with MIC values ranging from 2 to 64 ?g/mL. Moreover, compound 9 displayed considerable inhibitory activity against the THP-1 cell line in vitro, with an IC50 value of 7.0 ?g/mL.

SUBMITTER: Li ZX 

PROVIDER: S-EPMC6225247 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus <i>Aspergillus tennesseensis</i>.

Li Zhao-Xia ZX   Wang Xiu-Fang XF   Ren Guang-Wei GW   Yuan Xiao-Long XL   Deng Ning N   Ji Gui-Xia GX   Li Wei W   Zhang Peng P  

Molecules (Basel, Switzerland) 20180917 9

Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure-diorcinol L (<b>1</b>) and (<i>R</i>)-diorcinol B (<b>2</b>)-were isolated from the marine algal-derived endophytic fungus <i>Aspergillus tennesseensis</i>, along with seven known compounds: (<i>S</i>)-diorcinol B (<b>3</b>), 9-acetyldiorcinol B (<b>4</b>), dio  ...[more]

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