Ontology highlight
ABSTRACT:
SUBMITTER: Dasgupta S
PROVIDER: S-EPMC6267258 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Virchows Archiv : an international journal of pathology 20180906 6
Differentiated vulvar intraepithelial neoplasia (dVIN) is the precursor lesion of HPV-negative vulvar squamous cell carcinoma (VSCC). The histopathological diagnosis of dVIN can be challenging, as it often resembles vulvar non-neoplastic epithelial disorders (NNED), especially lichen sclerosus (LS). We aimed to establish the most specific and reproducible histological features of dVIN and assessed cytokeratin 13 (CK13) and cytokeratin 17 (CK17) immunohistochemistry as a diagnostic aid. Consecuti ...[more]