Safety and Short-Term Efficacy of Irreversible Electroporation and Allogenic Natural Killer Cell Immunotherapy Combination in the Treatment of Patients with Unresectable Primary Liver Cancer.

ABSTRACT: PURPOSE:This study aimed to investigate the safety and short-term efficacy of irreversible electroporation (IRE) combined with allogenic natural killer (NK) cell immunotherapy in the treatment of patients with unresectable primary liver cancer. MATERIALS AND METHODS:Between October 2015 and December 2016, 40 patients were enrolled and randomly allocated to either the IRE group (n?=?22) or the IRE-NK group (n?=?18). All adverse events experienced by the patients were recorded; the changes in tumor biomarkers [AFP, CA 19-9, circulating tumor cells (CTCs)], lymphocyte number and function, quality of life, clinical response, progression-free survival (PFS) and overall survival (OS) were assessed. RESULTS:Patients who received combination therapy exhibited significantly longer median PFS and OS than who just received IRE (PFS 15.1 vs. 10.6 months, P?

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6267679 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature