Ontology highlight
ABSTRACT:
SUBMITTER: Bowden J
PROVIDER: S-EPMC6269239 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bowden Jack J Hemani Gibran G Davey Smith George G
American journal of epidemiology 20181201 12
Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new approaches for MR analysis. The recently proposed "global and individual tests for direct effects" (GLIDE) approach fits into a family of methods that aim to detect horizontal pleiotropy-at the individual sing ...[more]