Ontology highlight
ABSTRACT:
SUBMITTER: Shapland CY
PROVIDER: S-EPMC9303808 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Shapland Chin Yang CY Zhao Qingyuan Q Bowden Jack J
Statistics in medicine 20220120 6
Two-sample summary data Mendelian randomization is a popular method for assessing causality in epidemiology, by using genetic variants as instrumental variables. If genes exert pleiotropic effects on the outcome not entirely through the exposure of interest, this can lead to heterogeneous and (potentially) biased estimates of causal effect. We investigate the use of Bayesian model averaging to preferentially search the space of models with the highest posterior likelihood. We develop a Metropoli ...[more]