Ontology highlight
ABSTRACT:
SUBMITTER: Durgeau A
PROVIDER: S-EPMC6269466 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Durgeau Aurélie A Virk Yasemin Y Gros Gwendoline G Voilin Elodie E Corgnac Stéphanie S Djenidi Fayçal F Salmon Jérôme J Adam Julien J de Montpréville Vincent V Validire Pierre P Ferrone Soldano S Chouaib Salem S Eggermont Alexander A Soria Jean-Charles JC Lemonnier François F Tartour Eric E Chaput Nathalie N Besse Benjamin B Mami-Chouaib Fathia F
Nature communications 20181130 1
Tumours often evade CD8 T-cell immunity by downregulating TAP. T-cell epitopes associated with impaired peptide processing are immunogenic non-mutated neoantigens that emerge during tumour immune evasion. The preprocalcitonin (ppCT)<sub>16-25</sub> neoepitope belongs to this category of antigens. Here we show that most human lung tumours display altered expression of TAP and frequently express ppCT self-antigen. We also show that ppCT includes HLA-A2-restricted epitopes that are processed by TAP ...[more]