Ontology highlight
ABSTRACT:
SUBMITTER: Fereidoonnezhad M
PROVIDER: S-EPMC6269558 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Fereidoonnezhad Masood M Mostoufi Azar A Eskandari Maryam M Zali Samaneh S Aliyan Fariba F
Iranian journal of pharmaceutical research : IJPR 20180101 4
Alzheimer's disease (AD) as a complicated and progressive neurodegenerative disorder is the most common form of dementia and memory loss. On account of the multifactorial etiology of AD, the multi-target-directed ligand (MTDL) approach is a promising method in searching new drug candidates for this disease. Here, in this paper more than 500 tacrine-coumarin hybrids have been designed and drug-likeness, molecular docking and descriptor analysis of them were performed to find out a drug candidate ...[more]